Saint-Louis Hospital coordinates 14 French PNH competence centres, but only 24 of the 50-plus centres in the national clone-observatory network actively report data.
French PNH expertise is organised, not scattered, around a single MaRIH-coordinated reference structure. Saint-Louis Hospital (AP-HP) in Paris holds the national reference centre for PNH, coordinating a network of 14 adult and pediatric competence centres across the country, including Robert-Debré Hospital, the pediatric competence site in Paris. That structure sits inside the Filière de Santé Maladies Rares Immuno-Hématologiques (MaRIH), France's designated rare-disease network for immuno-haematological conditions. Our KOL Universe gate (K1) starts by mapping this reference-and-competence-centre hierarchy before any single physician is scored.
A second, overlapping structure matters just as much for tiering: the French National Observatory of PNH Clones, a flow-cytometry harmonization network launched in 2010 spanning more than 50 French-speaking centres, of which only 24 currently submit validated clone data. A physician practicing at Saint-Louis, the coordinating reference centre for both structures, carries different scientific weight than one at a competence centre that participates in neither network, and our Tier Classification gate (K2) scores that distinction directly, alongside authorship on the PMSI-derived national cohort studies that increasingly anchor French PNH epidemiology. No named individual enters the workbook without a verification tag. Every KOL identity is checked against live publication records and institutional affiliations, then marked Verified, Industry benchmark, or Requires client validation.
France's PNH reference network, one coordinating hospital, 14 competence centres, and a 50-plus-centre observatory
| Institution / Network | Location / Scope | Role in Network |
|---|---|---|
| Saint-Louis Hospital (AP-HP) | Paris | National reference centre; MaRIH-coordinated |
| Robert-Debré Hospital | Paris | Pediatric competence centre |
| 14 competence centres (MaRIH network) | Nationwide | Adult and pediatric competence sites |
| French National Observatory of PNH Clones | Nationwide (24 of 50+ centres reporting) | Flow-cytometry harmonization and clone-validation network |
Sources: MaRIH (Filière de Santé Maladies Rares Immuno-Hématologiques) reference centre documentation; First Interim Analysis of the French National Observatory of Paroxysmal Nocturnal Hemoglobinuria Clones, Blood 130(Suppl 1):4960, 2017.
What this workbook answers
Every section answers a named commercial question your team is asking, scoped to your asset.
Delivers
- The Saint-Louis Hospital-coordinated, 14-competence-centre MaRIH network
- reference-centre structure as a KOL-tiering signal
- K1 KOL Universe Sizing methodology
Delivers
- K2 Tier Classification methodology
- dual-network participation (MaRIH competence centre plus clone-observatory reporting) as a weighting input
- K3 Scientific Influence scoring inputs
Delivers
- The three-tag verification protocol (Verified/Industry benchmark/Requires client validation)
- live publication and institutional-affiliation cross-checks
- why no placeholder name ships unflagged
Custom workbook delivered in 72 hours.
Commission This WorkbookWhat's inside
- Why institutional concentration, not scattergun individual outreach, is the single variable this workbook sizes first
- Pressure-tested against the Saint-Louis-coordinated MaRIH network case before the rest of the workbook is built out
- Every French PNH KOL sized and sourced from publication and institutional-affiliation data
- The Saint-Louis Hospital-coordinated, 14-competence-centre MaRIH network as the sizing anchor
- Universe boundaries: who counts as a KOL versus a high-volume prescriber
- Scientific-influence scoring across MaRIH competence-centre role and clone-observatory reporting participation
- What separates a Tier 1 KOL from a high-volume community prescriber
- Influence inputs: PMSI-cohort authorship, observatory-network reporting, institutional role
- Cross-checked against independent publication and citation data
- Readiness scoring and channel recommendations per KOL
- Sequencing implications for MSL deployment
- Territory-to-KOL coverage map across Paris and the 14 regional competence centres
- Where current MSL deployment has gaps
- Multi-market reach for KOLs active beyond France, across EU5 and wider European registries
- Implications for coordinated versus purely local engagement
- The open KOL-engagement questions your medical affairs team must close
- Structured for an internal alignment session before MSL deployment
Included with every brief
How AXLRx builds this workbook
Prepared by MoatRx analysts.
Every AXLRx KOL workbook is built from live publication records and institutional-affiliation data, not secondary summaries. No KOL name ships without a verification tag.
France PNH KOL sources: MaRIH (Filière de Santé Maladies Rares Immuno-Hématologiques) reference centre documentation and the First Interim Analysis of the French National Observatory of Paroxysmal Nocturnal Hemoglobinuria Clones, Blood 2017, plus the institutional affiliations named in that documentation.
- Saint-Louis Hospital coordinating role and the 14-competence-centre count verified against MaRIH reference centre documentation
- Observatory network size (50+ centres) and active-reporting count (24 centres) verified against the First Interim Analysis of the French National Observatory of PNH Clones, Blood 2017
- Every KOL entry in the underlying workbook carries a three-tag verification status before delivery: Verified, Industry benchmark, or Requires client validation
Frequently asked questions
Commission this workbook
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